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designed the cloning approach and expressed, purified, characterized recombinant wild type GPX4 protein, and performed the in-cell compound-binding assay

Mattson MP, Duan W, Guo Z

In this article, we present the basic views on oxidative damage to macromolecular compounds and the role of potential antioxidants in reducing neurodegenerative neurological diseases

Furthermore, ferroptosis-related genes (FRGs) show promise as prognostic biomarkers for MM patients ( This review systematically elucidates the molecular mechanisms of ferroptosis, its interplay with MM pathogenesis, and pharmacologic strategies leveraging ferroptosis modulation for MM intervention

They can also modulate the intestinal epithelial cell response and promote normal neonatal development through interactions with the gut flora